Mutations of the gene coding for calreticulin (CALR) that cause the loss of the C-terminal KDEL motif abolish its retention in the endoplasmic reticulum and cause CALR to be secreted from cells.Specific CALR mutants bearing a novel C-terminus can precipitate the manifestation of myeloproliferative diseases via the Holiday Decorations autocrine acti

Abstract Recently discovered Higgs particle is a key element in the standard model of elementary particles and its analogue in materials, massive Higgs mode, has elucidated intriguing collective Hats phenomena in a wide range of materials with spontaneous symmetry breaking such as antiferromagnets, cold atoms, superconductors, superfluids, and char

Black bears (Ursus americanus) are an iconic and common species throughout much of the United States and people regularly interact with these large predators without conflict.However, negative interactions between people and bears can manifest in conflicts that can hinder conservation efforts.Black bears are highly attracted to anthropogenic source

The existing flare prediction primarily relies on photospheric magnetic field parameters from the entire active region (AR), such as Space-Weather HMI Activity Region Patches (SHARP) parameters.However, these parameters may not capture the details Strut Lifter Switch of the AR evolution preceding flares.The magnetic structure within the core area o

Stress Travel Neck Pillow is crucial to the survival of an organism, but excessive stress can lead to psychological disorders including depression, anxiety, substance abuse, and suicidality.The prevailing notion is that chronic stress promotes adverse outcomes on brain and body health, whereas acute stressors are generally benign.Notably, acute eve